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Index > Protein center > Vcl(Gene name) > Rat
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  • Vcl (Gene name),
  • Vinculin (Protein name ),  VINC_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Vcl;
    Protein name:
    Vinculin;
    Alternative:
    Metavinculin;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Exhibits self-association properties. Interacts with NRAP, SORBS1 and TLN1. Interacts with SYNM. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin.
    Function:
    Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
    Subcellular Location:
    Cytoplasm cytoskeleton Cell junction adherens junction Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions.
    Protein Attributes:
    Sequence length:
    1066
    Sequence:
    50:
    MPVFHTRTIE | SILEPVAQQI | SHLVIMHEEG | EVDGKAIPDL | TAPVAAVQAA | 
    100:
    VSNLVRVGKE | TVQTTEDQIL | KRDMPPAFIK | VENACTKLVQ | AAQMLQSDPY | 
    150:
    SVPARDYLID | GSRGILSGTS | DLLLTFDEAE | VRKIIRVCKG | ILEYLTVAEV | 
    200:
    VETMEDLVTY | TKNLGPGMTK | MAKMIDERQQ | ELTHQEHRVM | LVNSMNTVKE | 
    250:
    LLPVLISAMK | IFVTTKNSKN | QGIEEALKNR | NFTVGKMSAE | INEIIRVLQL | 
    300:
    TSWDEDAWAS | KDTEAMKRAL | ASIDSKLNQA | KGWLRDPNAS | PGDAGEQAIR | 
    350:
    QILDEAGKVG | ELCAGKERRE | ILGTCKMLGQ | MTDQVADLRA | RGQGASPVAM | 
    400:
    QKAQQVSQGL | DVLTAKVENA | ARKLEAMTNS | KQSIAKKIDA | AQNWLADPNG | 
    450:
    GPEGEEQIRG | ALAEARKIAE | LCDDPKERDD | ILRSLGEIAA | LTSKLGDLRR | 
    500:
    QGKGDSPEAR | ALAKQVATAL | QNLQTKTNRA | VANSRPAKAA | VHLEGKIEQA | 
    550:
    QRWIDNPTVD | DRGVGQAAIR | GLVAEGHRLA | NVMMGPYRQD | LLAKCDRVDQ | 
    600:
    LAAQLADLAA | RGEGESPQAR | ALASQLQDSL | KDLKTQMQEA | MTQEVSDVFS | 
    650:
    DTTTPIKLLA | VAATAPPDAP | NREEVFDERA | ANFENHSGRL | GATAEKAAAV | 
    700:
    GAANKSTVEG | IQASVKTARE | LTPQVISAAR | ILLRNPGNQA | AYEHFETMKN | 
    750:
    QWIDNVEKMT | GLVDEAIDTK | SLLDASEEAI | KKDLDKCKVA | MANIQPQMLV | 
    800:
    AGATSIARRA | NRILLVAKRE | VENSEDPKFR | EAVKAASDEL | SKTISPMVMD | 
    850:
    AKAVAGNISD | PGLQKSFLDS | GYRILGAVAK | VREAFQPQEP | DFPPPPPDLE | 
    900:
    QLRLTDELAP | PKPPLPEGEV | PPPRPPPPEE | KDEEFPEQKA | GEVINQPMMM | 
    950:
    AARQLHDEAR | KWSSKGNDII | AAAKRMALLM | AEMSRLVRGG | SGTKRALIQC | 
    1000:
    AKDIAKASDE | VTRLAKEVAK | QCTDKRIRTN | LLQVCERIPT | ISTQLKILST | 
    1050:
    VKATMLGRTN | ISDEESEQAT | EMLVHNAQNL | MQSVKETVRE | AEAASIKIRT | 
    1066:
    DAGFTLRWVR | KTPWYQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Vinculin
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    CLIA Kit for Rat Vinculin
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    CLIA Kit for Rat Vinculin
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    U1839c
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    CLIA Kit for Rat Vinculin
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    U1839r
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    CLIA Kit for Rat Vinculin
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    U1839m
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    Polyclonal Antibody for Rat Vinculin
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    P1839Rb-h
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    Polyclonal Antibody for Rat Vinculin
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    Packing:
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    Polyclonal Antibody for Rat Vinculin
    Polyclonal Antibody for Rat Vinculin
    Polyclonal Antibody for Rat Vinculin
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    P1839Rb-r
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    Packing:
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    Monoclonal Antibody for Rat Vinculin
    Monoclonal Antibody for Rat Vinculin
    Monoclonal Antibody for Rat Vinculin
    Monoclonal Antibody for Rat Vinculin
    Monoclonal Antibody for Rat Vinculin
    Protein for Rat Vinculin
    Protein for Rat Vinculin
    Protein for Rat Vinculin
    Protein for Rat Vinculin
    Protein for Rat Vinculin

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    References
    1. 1.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    2. 2.
      "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
      Hoffert J.D. , Pisitkun T. , Wang G. , Shen R.-F. , Knepper M.A.
      Proc. Natl. Acad. Sci. U.S.A.103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-290;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    3. 3.
      "Proteome profile of the mature rat olfactory bulb."
      Maurya D.K. , Sundaram C.S. , Bhargava P.
      Proteomics9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION
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